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ChemInform Abstract: Synthesis and Antiviral and Antineoplastic Activities of Some Novel Carbocyclic Guanosine Analogues with a Cyclobutane Ring
- Source :
- ChemInform. 31
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were prepared from (1R,cis)-3-aminomethyl-2,2-dimethylcyclobutylmethanol (1). All were evaluated as antiviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........be4e120af8618db99c9432b36eb03d50