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Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth

Authors :
Chunyong Ding
Mengyan Du
Zhi Xiong
Xue Wang
Hongji Li
Ende He
Han Li
Yijing Dang
Qing Lu
Shicong Li
Ruoxuan Xiao
Zhiai Xu
Lili Jing
Liufu Deng
Xiyuan Wang
Meiyu Geng
Zuoquan Xie
Ao Zhang
Source :
Chemical Science.
Publication Year :
2023
Publisher :
Royal Society of Chemistry (RSC), 2023.

Abstract

A photo-caged STING agonist featuring a tumor-targeting carbonic anhydrase warhead was designed and synthesized for photo-controllable activation of STING signaling.

Subjects

Subjects :
General Chemistry

Details

ISSN :
20416539 and 20416520
Database :
OpenAIRE
Journal :
Chemical Science
Accession number :
edsair.doi...........bdcbc15d39a638c73b2c1a85fff8b422
Full Text :
https://doi.org/10.1039/d3sc01896b