Reaction of Bromoacetyl and Sulfhydryl Groups: Efficient Synthesis of Aromatic Oligoamides Consisting of Benzene-1,3,5-tricarboxamide Units

A series of aromatic oligoamides consisting of benzene-1,3,5-tricarboxamide (BTA) residues linked by thioether bonds were designed and synthesized based on the highly efficient and specific reaction between sulfhydryl and bromoacetyl groups. Initial assessment of the folding of these oligoamides with circular dichroism (CD) spectroscopy showed that these oligoamides could fold into a helical conformation.