(157) Humans with Inducible Symptoms of Low Back Pain Show Intervertebral Disc Changes in the Lumbar Spine during Prolonged Standing

LBP symptoms can be induced in back-healthy individuals in prolonged standing and are relieved upon exiting standing [1]. These individuals who develop LBP (pain developers -PDs) are 3 times more likely to develop a clinical episode of LBP within two years than their non-pain developer (NPD) counterparts [2]. Yet the specific anatomical changes that provoke these LBP symptoms remain unknown. We hypothesized that PDs have distinct adaptations in each intervertebral disc (IVD) level compared to NPDs. We investigated the changes in spinal alignment (Cobb angle) and local IVD structure over time in PDs. Forty human subjects (age 18-30, BMI