Pyogenic Bacterial Infections in Humans With MyD88 Deficiency

von Bernuth H, Picard C, Jin Z, et al. Science . 2008;321(5889):691–696 PURPOSE OF THE STUDY. Myeloid differentiation protein 88 (MyD88) is a key downstream adapter for receptors of the innate immune system, including most Toll-like receptors (TLRs) and interleukin 1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens, and the goal of this study was to determine whether there are children with recurrent infections who have a deficiency in MyD88. STUDY POPULATION. Nine children with MyD88 deficiency were identified from those evaluated for …