Back to Search
Start Over
ChemInform Abstract: A Rational Eco-Compatible Design Strategy for Regio- and Diastereoselective Synthesis of Novel Dispiropyrrolidine/Thiapyrrolizidine Hybrids
- Source :
- ChemInform. 46
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- A facile regio- and stereoselective synthesis of novel dispiroheterocyclic hybrids containing benzo[1,4]oxazine/benzo[1,4]thiazine and pyrrolidine/thiapyrrolizidine moieties via 1,3-dipolar cycloaddition reaction was carried out. The reaction has been carried out using 2,2,2-trifluoroethanol as a new alternative green solvent and catalyst for rapid access to construct a diversity-oriented library of regioselectivity dispiropyrrolidine/thiapyrrolizidines. Mild reaction conditions with excellent conversion, higher yields in shorter reaction times and the easy recyclability of 2,2,2-trifluoroethanol makes this protocol attractive, sustainable and environmentally benign.
Details
- ISSN :
- 09317597
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........bd765590b7ed17111199fe71dc3af824