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Structural characterization, electronic properties, and anxiolytic-like effect in adult zebrafish (Danio rerio) of cinnamaldehyde chalcone
- Source :
- Journal of Molecular Structure. 1222:128954
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Zebrafish is a model animal that is used for neurobehavioral studies. It is an excellent model organism for pharmacological studies and/or safety research at an early stage of drug development. In this work, the chalcone (2E, 4E)-1-(2‑hydroxy-3,4,6-trimethoxyphenyl)-5-phenylpenta-2,4‑dien‑1-one, was synthesized by the Claisen-Schmidt condensation from two natural products: 2‑hydroxy-3,4,6-trimethoxyacetophenone and cinnamaldehyde. The molecular structure of this compound was confirmed by spectroscopic methods such as NMR, Infrared, UV–vis, and quantum chemical calculations. In addition, the anxiolytic-like effect of the cinnamaldehyde chalcone in adult zebrafish (Danio rerio) was evaluated. The results showed that chalcone caused an approximately 80% reduction in zebrafish locomotor activity and induced maximum permanence of zebrafish in the clear zone (61.16%) at a dose of 0.5 mg kgl−1. The data suggest that the cinnamaldehyde chalcone has anxiolytic activity.
- Subjects :
- Chalcone
animal structures
medicine.drug_class
Stereochemistry
ved/biology.organism_classification_rank.species
Danio
010402 general chemistry
01 natural sciences
Anxiolytic
Cinnamaldehyde
Analytical Chemistry
Anxiolytic like
Inorganic Chemistry
chemistry.chemical_compound
medicine
Model organism
Zebrafish
Spectroscopy
Electronic properties
biology
010405 organic chemistry
Chemistry
ved/biology
Organic Chemistry
biology.organism_classification
0104 chemical sciences
Subjects
Details
- ISSN :
- 00222860
- Volume :
- 1222
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Structure
- Accession number :
- edsair.doi...........bd5492e73f8b89ff77e5d4cbe0b7c5d2