Characterization of endo-metabolome exhibiting antimicrobial and antioxidant activities from endophytic fungus Cercospora sp. PM018

In the context of increasing demand for novel pharmaceutical high-value compounds and their natural sources, endophytic fungi from medicinal plants are being recently explored for diverse bioactive metabolites. We report bioprocess optimization and biochemical characterization of the endo-metabolome possessing broad-spectrum antimicrobial and antioxidant activities, from an endophytic fungus Cercospora sp. PM018 that was isolated from Lal-bisalyakarani (Aerva javanica Juss. Ex.Schult, an Indian indigenous medicinal plant). Potato dextrose medium having pH 4.0 and incubation temperature of 30 °C were found to be optimal for the enhanced bioactivities of the endo-metabolome after 12 days of fungal growth. In the antibiotic-potentiating assay, fractional inhibitory concentration