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Subcutaneous administration of recombinant human acid α-glucosidase co-formulated with the pharmacological chaperone AT2220 leads to lysosomal uptake of rhGAA and glycogen reduction in disease-relevant tissues of mice with Pompe disease

Authors :
Yi Lun
Jessie Feng
Su Xu
Kenneth J. Valenzano
Anadina Garcia
Lee Pellegrino
Rebecca Soska
Michelle Frascella
Richie Khanna
John J. Flanagan
David J. Lockhart
Source :
Molecular Genetics and Metabolism. 111:S73
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Details

ISSN :
10967192
Volume :
111
Database :
OpenAIRE
Journal :
Molecular Genetics and Metabolism
Accession number :
edsair.doi...........bcfbb28a7d24f860c64576b86b1561d2
Full Text :
https://doi.org/10.1016/j.ymgme.2013.12.167