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Association Study of Human MTH1 Ile45Thr Polymorphism with Sporadic Parkinson’s Disease
- Source :
- European Neurology. 59:15-17
- Publication Year :
- 2007
- Publisher :
- S. Karger AG, 2007.
-
Abstract
- Human MTH1, an oxidized purine nucleoside triphosphatase, hydrolyzes 8-oxo-dGTP thereby preventing its misincorporation into DNA. The present study was designed to investigate a possible link between the MTH1 Ile45Thr polymorphism and the development of sporadic Parkinson disease (PD). This case-control study consisted of 106 PD patients and 135 unrelated controls. MTH1 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results showed that Ile45/Thr45 heterozygote and Thr45 allele tended to be more frequent in sporadic PD, although statistically not significant (0.085 vs. 0.044, corrected p = 0.591 and 0.052 vs. 0.022, p = 0.080, respectively). Stratification analysis by gender showed that Ile45/Thr45 heterozygote tended to be more frequent in male PD patients than in male controls (0.113 vs. 0.038, corrected p = 0.480). The male PD patients exhibited a borderline statistically significant higher frequency of the Thr45 allele than the controls (0.073 vs. 0.019, corrected p = 0.050). These results suggested to us that the Thr45 allele of MTH1 might be associated with sporadic PD in the Chinese male population.
- Subjects :
- Purine
medicine.medical_specialty
Parkinson's disease
Heterozygote advantage
Biology
medicine.disease_cause
medicine.disease
Molecular biology
chemistry.chemical_compound
Endocrinology
Neurology
chemistry
Internal medicine
medicine
Neurology (clinical)
Sporadic Parkinson disease
Allele
Allele frequency
Chi-squared distribution
Oxidative stress
Subjects
Details
- ISSN :
- 14219913 and 00143022
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- European Neurology
- Accession number :
- edsair.doi...........bcb9c08d049c662fe4bcbb79aeb38798
- Full Text :
- https://doi.org/10.1159/000109255