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Ингибирование нерецепторной тирозинкиназы JAK2 снижает рост клеток нейробластомы и усиливает действие доксорубицина
- Source :
- Молекулярная биология. 54:293-299
- Publication Year :
- 2020
- Publisher :
- The Russian Academy of Sciences, 2020.
-
Abstract
- Novel treatments for various types of malignant diseases are warranted. In this study, we evaluated JAK2 inhibitors (Janus kinase 2) for suppressing the growth of malignant neuroblastoma and glioblastoma cells as well as breast and non-small cell lung cancers. Neuroblastoma and glioblastoma cells are the most sensitive to the JAK2 inhibitor AG490. A study of the relative expression of receptors that can activate JAK2 suggests that cell line sensitivity to AG490 may be mediated by IL6-R, IL11-R and/or CSF1-R. AG490 enhances the effect of doxorubicin on neuroblastoma cells. Our findings suggest the possible relevance of JAK2 inhibitors for neuroblastoma therapy, especially in combination with doxorubicin.
Details
- ISSN :
- 00268984
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Молекулярная биология
- Accession number :
- edsair.doi...........bca7d14f107c3a4ab748eabecb07a4b3