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Effect of PM2.5 exposure on circulating fibrinogen and IL-6 levels: A systematic review and meta-analysis
- Source :
- Chemosphere. 271:129565
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Ambient fine particulate matter (PM2.5) pollution poses a great threat on global health. Previous studies have reported that PM2.5 regulates circulating fibrinogen and IL-6 levels in the development of cardiovascular and respiratory disease. However, the correlation between PM2.5 exposure and both biomarkers remains inconsistent. Methods We searched related articles through PubMed, Web of Science and ScienceDirect. Random effects model was used to obtain a pooled estimate effect of both biomarkers as PM2.5 concentration increased by every 10 μg/m3. Meta-regression analysis, sensitivity analysis and publication bias test were conducted to evaluate the heterogeneity, stability and reliability of this meta-analysis. Results A total of 22 articles were included. Each 10 μg/m3 increase in PM2.5 concentration was significantly correlated with a 1.76% increase in circulating fibrinogen level (95% CI: 0.38%–3.14%, P = 0.013) and a 4.66% increase in IL-6 level (95% CI: 1.14%–8.18%, P = 0.010). Subgroup analysis revealed that high-level PM2.5 exposure had a more significant association with circulating IL-6 level (11.67%, 95% CI: 0.66%–22.69%, P = 0.038) than low-level exposure, but this association was not observed in fibrinogen (2.50%, 95% CI: −0.78%–5.77%, P = 0.135). Sensitivity analysis and publication bias test confirmed the stability of the results. Conclusion Circulating fibrinogen and IL-6 significantly increased with exposure to PM2.5, may serve as promising biomarkers for PM2.5-related adverse effects.
- Subjects :
- medicine.medical_specialty
Environmental Engineering
Fine particulate
Health, Toxicology and Mutagenesis
0208 environmental biotechnology
Subgroup analysis
02 engineering and technology
010501 environmental sciences
Fibrinogen
complex mixtures
01 natural sciences
Gastroenterology
Internal medicine
medicine
Environmental Chemistry
Interleukin 6
Adverse effect
0105 earth and related environmental sciences
biology
business.industry
Respiratory disease
Public Health, Environmental and Occupational Health
General Medicine
General Chemistry
Publication bias
medicine.disease
Pollution
020801 environmental engineering
Meta-analysis
biology.protein
business
medicine.drug
Subjects
Details
- ISSN :
- 00456535
- Volume :
- 271
- Database :
- OpenAIRE
- Journal :
- Chemosphere
- Accession number :
- edsair.doi...........bc9488c2f82c5a00bfaef7ea77605cca
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2021.129565