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Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt-Jakob disease
- Source :
- Annals of Neurology. 80:629-632
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629-632.
- Subjects :
- 0301 basic medicine
Gait instability
Pathology
medicine.medical_specialty
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Sporadic Creutzfeldt-Jakob disease
Asymptomatic
03 medical and health sciences
Occipital Cortices
030104 developmental biology
0302 clinical medicine
Neurology
medicine
Neurology (clinical)
Gene sequence
Cognitive decline
Prion protein
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 03645134
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi...........bc4d64c3c7df17d2f253312eda62810a