Evidence for a Link Between Adipose Tissue Interleukin-6 Content and Serum C-Reactive Protein Concentrations in Obese Subjects

To the Editor: We read with interest the editorial by Tracy1 on inflammation in cardiovascular disease (CVD). Serum concentrations of C-reactive protein (CRP) were demonstrated to be related to increased risk of CVD, which underlines the potential inflammatory nature of human atherosclerosis.2 3 Interestingly, an unexpected association between CRP and body mass index (BMI) was found in several population studies2 3 4 without any explanation.1 The production of CRP is regulated by cytokines, …