A single-institution (MSKCC) analysis of incidence and clinical outcomes in patients with thromboembolic events and exocrine pancreas cancer

4062 Background: Pancreas adenocarcinoma (PC) is one of the most common malignancies associated with venous thromboembolism (VTE), but reported incidence ranges vary and contain relatively small patient subsets. Little has been described about arterial thrombotic events (ATE) in PC, as well as the correlation between VTE timing and patient outcomes. Methods: We identified a total of 6,870 patients with PC seen at our institution from 1/1/00 to 12/31/09. Using ICD codes, we analyzed subsets of this patient group with VTE or ATE. Demographic data included vital status, age at diagnosis of PC, timing of thrombotic event (TE), and thrombosis treatment. Results: Any thrombosis was identified in 1,322 (19%), of which 1,179 (17%) had VTE, 143 (2%) had ATE, and 64 (0.9%) of patients had both an ATE and VTE. 290 (25%) of the VTE patients had pulmonary embolism (PE). For patients in whom treatment information was available, low molecular weight heparin (LMWH) was prescribed in 95% and fondaparinux in 6%. 0.4% recei...