A U. S. P. gelatin vehicle in liquid form for retardation of absorption with special reference to epinephrine

1.1. A simple and effective way of preparing a gelatin vehicle for subcutaneous injection where a slow acting pharmacologic effect is desired is described. 2.2. The method consists in adding sufficient urea to the gelatin solution to maintain the gel in the sol state at room temperature. 3.3. Experiments on plasticity have shown that an 8.5 per cent solution of gelatin plus 15 per cent urea becomes and remains liquid at room temperature when removed from the refrigerator. 4.4. The mixture does not readily support the growth of bacteria. 5.5. The experiments and clinical trials reported illustrate that this preparation is suitable for the administration of epinephrine as well as other drugs and biologically active substances where retardation of the pharmacologic effect is desired.