Activity of Ethanol Extract of Tinospora crispa (L.) Hook in Increasing Swimming Endurance on Male Mice Using Natatory Exhaustion Method

The use of stamina-enhancing drugs is now increasingly widespread. Continuous use of stamina medication can cause side effects such as insomnia, feeling nervous and emotional. Therefore, it is necessary to look for effective drugs, relatively low side effects, and relatively cheap prices. One of them is to use natural materials such as Tinospora crispa (L.) Hook stems. This study is to find out the tonic effect extract ethanol of Tinospora crispa stem against male mice with the Natatory Exhaustion Method. This research is an experimental study with a posttest matched control group design. Tonic effect test experiments were conducted using the Natatory Exhaustion Method. Test animals as many as 25 mice were divided into 5 groups, group I, II, III has given Tinospora crispa stem ethanol extract (100,200 and 400 mg/kg body weight). Group IV was given 100 mg/kg body weight of caffeine (positive control) and group V given 25 mL/kg body weight of Carboxymethylcellulose sodium 0.5 % (negative control). Test reserved per oral for 14 days. Test showing that administration 100, 200, and 400 mg/kg body weight of Tinospora crispa stem ethanol extract gave tonic effect on male mice. Mann-Whitney tests showed that the administration of Tinospora crispa stem ethanol extract doses of 100, 200, and 400 mg/kg body weight gave a tonic effect on male mice with significant value (p