AB0877 OXIDIZED LOW DENSITY LIPOPROTEIN IS CORRELATED WITH INFLAMMATORY STATUS IN GOUTY ARTHRITIS

Background Lipid peroxidation and oxidized LDL (oxLDL) are hallmarks in the development of various metabolic, cardiovascular and other inflammatory diseases. Cholesterol crystals and oxLDL, which are considerably present in atherosclerotic plaques, can activate inflammasomes. The concentration of plasma ox-LDL was also closely associated with the high incidence of atherosclerotic diseases in patients with gout might be closely related to increased ox-LDL levels. However, the study about the relationship between the level of ox-LDL and the inflammatory status in gout patients are rare. Objectives We aimed to the relationships between ox-LDL level, inflammatory markers and uric acid lowering agents in gout patients. Methods One hundred seventy four gout patients were included from the 3 institutions from 2014 to 2017. Details of demographic and clinical features along with laboratory parameters, ESR, CRP, lipid profiles, oxLDL and disease status were noted in patients with gout. We classified inflammatory status as acute, subacute chronic tophaceous and well controlled status. The level of ox-LDL was measured using the latex enhanced immune transmission turbidimetric method. We analyzed the comparison between dermographics, inflammatory markers, lipid profiles and disease subset. Results The primary objective of this study was to assess the oxLDL according to inflammatory status in gouty arthritis. Mean age was 50.4 year-old, 85.7% was woman, 98.9% were male, mean BMI was 25.86 and mean disease duration was 48 months. Among 174 gout patients, 61 patients (35.1%) were acute flare-up, 38 patients (21.8%) were subacute, 67 patients (38.5%) were chronic tophaceous, and 7 patients (4%) were well controlled stable status. Age, sex, BMI, and accompanying disease were not statistically different in the 4 groups according to inflammatory status. However, it showed statistically significant differences in the use of glucocorticoid and uric acid lowering agents. There was no significant difference in uric acid in laboratory tests, but there was a significant difference between ESR and CRP in each disease group. Especially, oxLDL showed difference according to inflammatory state of disease. Conclusion The levels of oxLDL in gout patients were significantly different according to inflammatory status. The oxLDL may be associated with inflammation process in gout patients. Disclosure of Interests None declared