Science Signaling Podcast: 24 May 2011

This Podcast features conversations with authors of articles related to Hippo signaling that appear in Science and Science Signaling . James Martin discusses his group’s finding that Hippo signaling regulates the size of the mouse heart by antagonizing Wnt signaling through a mechanism that involves cooperation between the transcription factors Yap and β-catenin, as described in a Research Report published in the 22 April 2011 issue of Science . Valeri Vasioukhin and Mark Silvis discuss their findings related to Hippo signaling in tumorigenesis, as reported in the 24 May 2011 issue of Science Signaling . They report that the adhesion protein αE-catenin acts as a tumor suppressor by regulating the localization and activity of the transcriptional coactivator Yap, which is also regulated by Hippo signaling.