New Fluorine-Containing Derivatives of 4-Anilino-2-(methylsulfanyl)quinazolines

A number of new 4-anilinoquinazolines were synthesized starting from 6,7,8-trifluoro-2-(methyl­sulfanyl)quinazolin-4(3H)-one. Reactions of the title compounds with cyclic secondary amines involved substitu­tion of the 7-fluorine atom with retention of the methylsulfanyl group on C2. 6,7,8-Trifluoro-4-(2-me­thoxyanilno)-2-(methylsulfanyl)quinazoline showed in vitro tuberculostatic activity with a minimum inhibitory concentration of 1.5 μg/mL.