Back to Search
Start Over
Sensitivity of serum concentration of cartilage biomarkers to 21-days of bed rest
- Source :
- Journal of Orthopaedic Research®. 36:1465-1471
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- The objective of the study was to test the hypothesis that serum levels of cartilage oligomeric matrix protein (COMP) would decrease and serum levels of tumor-necrosis factor alpha (TNF-α) and selected matrix metalloproteinases (MMPs) would increase in response to bed rest (BR) and that these changes are unaffected by the intake of potassium bicarbonate or whey protein. Seven and nine healthy male subjects participated in two 21-day 6° head down tilt crossover BR-studies with nutrition interventions. Serum samples were taken before, during, and after BR and biomarker concentrations were measured using commercial enzyme-linked immunosorbent assays. MMP-3 during BR was significantly lower than at baseline (reduction greater 20%; p
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
Cartilage metabolism
Matrix metalloproteinase
Bed rest
Potassium bicarbonate
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Orthopedics and Sports Medicine
030203 arthritis & rheumatology
Cartilage oligomeric matrix protein
biology
business.industry
Cartilage
3. Good health
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
biology.protein
Biomarker (medicine)
Tumor necrosis factor alpha
business
Subjects
Details
- ISSN :
- 07360266
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Orthopaedic Research®
- Accession number :
- edsair.doi...........bb20b57ce0af5f39fac2951f42b45d5b