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Bilateral Lacrimal Gland Mantle Cell Lymphoma: A Case Report and Review of the Literature
- Source :
- Journal of Clinical & Experimental Ophthalmology.
- Publication Year :
- 2016
- Publisher :
- OMICS Publishing Group, 2016.
-
Abstract
- Background: In this report we will describe a case of mantle cell lymphoma (MCL) in the conjunctiva and underlying clinical, histologic, immunological and genetic findings jointly with review of current literature.Case presentation: Here we report a case of MCL presenting as bilateral conjunctival masses of a period of over four in a 70-year-old man.Method and results: Histological examination revealed a proliferation of monotonous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. The lymphoid infiltrate expressed CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11.Conclusion: We suggest a more focused approach to differential diagnosis of this cancer, as MCL is a more aggressive disease than other entities. Due to the rarity of this lymphoma a multidisciplinary team is essential to achieve the best therapeutic approach.
- Subjects :
- Pathology
medicine.medical_specialty
Conjunctiva
business.industry
Cancer
Lacrimal gland
medicine.disease
Lymphoma
03 medical and health sciences
0302 clinical medicine
Cyclin D1
medicine.anatomical_structure
immune system diseases
hemic and lymphatic diseases
030220 oncology & carcinogenesis
030221 ophthalmology & optometry
medicine
Mantle cell lymphoma
Differential diagnosis
CD5
business
Subjects
Details
- ISSN :
- 21559570
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical & Experimental Ophthalmology
- Accession number :
- edsair.doi...........bade9ffdc0f6f8e225c8f05b3be4b2af