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Oral Drug Delivery to the Experimental Animals, A Mini Review

Authors :
Mubashar Rehman
Ahmad Mohammadi
Aqsa Ameen
Rafia Inam
Arif Paiman
Source :
Global Drug Design & Development Review. :19-26
Publication Year :
2016
Publisher :
Humanity Only - HO, 2016.

Abstract

In several pharmacologic, pharmacology, and alternative medicine studies, oral administration of medication or test substances to experimental animals is needed. It is clinically sound and recommended to administer test substances to experimental animals along the same route that they are taken or expected to be taken by humans as general bioavailability; the pharmacology and pharmacology parameters obtained for the drug will depend significantly on the route chosen to administer it. The lack of ready access to high-quality oral tubing built for different species, as well as a widespread lack of technical expertise to properly use out-of-the-box techniques in this part of the world, has made this route controversial among medicine scientists. The typical problems and difficulties associated with the oral administration of test product solutions were avoided by mistreating either the syringe alone or incorporating it into the animals feeds or drinkables. This jury-rigged oral tubing was also used to ensure that the expected doses were correctly administered in each case.

Details

ISSN :
27884120 and 2788497X
Database :
OpenAIRE
Journal :
Global Drug Design & Development Review
Accession number :
edsair.doi...........bada836ee3b72069d8d2593e16981a38