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A Direct Synthesis of 3,5-Dibromo-O-methyl-L-tyrosine

Authors :
Jeremy Stewart
Jordan K. Zjawiony
Frank R. Fronczek
Hesham Fahmy
Isamu Katsuyama
Source :
ChemInform. 35
Publication Year :
2004
Publisher :
Wiley, 2004.

Abstract

A simple and efficient synthesis of 3,5‐dibromo‐O‐methyl‐L‐tyrosine is described by direct bromination of commercial O‐methyl‐L‐tyrosine with bromine in aqueous hydrochloric acid. MO calculations are presented to explain a difference in the degree of substitution of O‐methyl‐L‐tyrosine in different solvents.

Details

ISSN :
15222667 and 09317597
Volume :
35
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........baa3f76aca4dec67aef139abd3a70168
Full Text :
https://doi.org/10.1002/chin.200429180