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Triblock copolymers containing UCST polypeptide and poly(propylene glycol): Synthesis, thermoresponsive properties, and modification of PVA hydrogel
- Source :
- European Polymer Journal. 115:244-250
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A series of ABA-type triblock copolymers (PImBF4-b-PPG-b-PImBF4) comprising of poly(propylene glycol) (PPG) as middle block and UCST polypeptide on both sides of PPG was synthesized by ring-opening polymerization of γ-chloropropyl-L-glutamic acid-based N-carboxyanhydride (CPLG-NCA) and then side-chain modification including nucleophilic substitution of the chloro group followed by copper-mediated 1,3-dipolar cycloaddition and subsequent ion-exchange reaction. Variable-temperature UV–vis spectroscopy revealed that the upper critical solution temperature (UCST)-type cloud point temperature (Tcp) was highly dependent on both polypeptide and PPG chain length as well as polymer concentration. Increasing the polymer chain length or concentration frequently results in Tcp increases. Noticeable hysteresis in a cooling/heating cycle was observed for all resulting triblock copolymers owing to a slow disassembly of large aggregates (d = 145 nm) in the heating cycle. Moreover, the resulting UCST triblock copolymers were used to regulate the release property of ciprofloxacin (CIP)-loaded poly(vinyl alcohol) (PVA) hydrogel. The incorporation of PImBF4-b-PPG-b-PImBF4 hampered the burst release of CIP at 37 °C indicating their potential toward sustained release of drug-loaded hydrogels.
- Subjects :
- chemistry.chemical_classification
Vinyl alcohol
Cloud point
Polymers and Plastics
Organic Chemistry
General Physics and Astronomy
02 engineering and technology
Polymer
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Polyvinyl alcohol
0104 chemical sciences
chemistry.chemical_compound
chemistry
Chemical engineering
Polymerization
Upper critical solution temperature
Self-healing hydrogels
Materials Chemistry
Copolymer
sense organs
0210 nano-technology
Subjects
Details
- ISSN :
- 00143057
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- European Polymer Journal
- Accession number :
- edsair.doi...........baa2fb28e0fc8e8c6b7fe558079cebd2