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ChemInform Abstract: A New Stereoselective Synthesis of (20R)- and (20S)-Steroidal Side Chains
- Source :
- ChemInform. 19
- Publication Year :
- 1988
- Publisher :
- Wiley, 1988.
-
Abstract
- Reaction of (E)-ethyl 3β-t-butyldimethylsiloxypregna-5,17-dien-21-oate with lithium di-isopropylamide followed by alkyl halides results in the predominant formation of (20S)-alkylation products in >88% isolated yields; a synthetic application to both (20R)- and (20S)-steroidal side chains is also described.
Details
- ISSN :
- 09317597
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........ba3163f552e42d2d6b2fdf68ceac256c