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Electrochemical reduction of substituted pyridazines: a new access to activated pyrroles
- Source :
- Electrochimica Acta. 47:2833-2841
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The electrochemical two electron reduction of pyridazines, substituted by electron withdrawing groups, primarily lead to their corresponding 1,2-dihydro-derivatives. Depending on the nature of the ring substitution, these intermediates can either rearrange into 1,4-dihydro-pyridazines, or undergo electrochemical reduction to give rise to activated pyrroles by a ring contraction reaction with extrusion of nitrogen. Another way of access to the latter has been achieved by a disproportionation reaction of 1,2-dihydro-pyridazines, leading directly to the expected pyrroles and recovery of 50% of pyridazines.
Details
- ISSN :
- 00134686
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Electrochimica Acta
- Accession number :
- edsair.doi...........b9e363edf92e9fc5fe6c7495e016b7ea