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Fucoxanthin Isolated from Undaria pinnatifida Can Interact with Escherichia coli and lactobacilli in the Intestine and Inhibit the Growth of Pathogenic Bacteria
- Source :
- Journal of Ocean University of China. 18:926-932
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Fucoxanthin is a xanthophyll-type carotenoid that provides many benefits to human health. However, the mechanism by which fucoxanthin interacts with microbes and inhibits pathogenic bacteria is unknown. In this study, we investigated the effects of fucoxanthin isolated from the edible seaweed Undaria pinnatifida on pathogenic bacteria Escherichia coli and lactobacilli both in vitro and in vivo. Fucoxanthin strongly inhibited the growth of Gram-positive pathogenic bacteria but was less effective against Gram-negative bacteria. Fucoxanthin extracted from the crude mixture had a recovery rate of 93.38% and a purity of 82.70%, which were higher than those of fucoxanthin extracted using a previous method. Fucoxanthin also promoted the growth of intestinal microbes in mice. Fucoxanthinol, a metabolite of fucoxanthin, was generated in the culture media. Fucoxanthin can be deacetylated into fucoxanthinol not only by conventional digestive enzymes in the digestive tract, but also by E. coli and lactobacilli in the intestine. These results indicate that fucoxanthin interacts with and influences E. coli and lactobacilli in the intestine. Therefore, fucoxanthin isolated from Undaria pinnatifida possibly can be applied in human health maintenance.
- Subjects :
- chemistry.chemical_classification
Gram-negative bacteria
biology
Gram-positive bacteria
Microorganism
food and beverages
Ocean Engineering
Pathogenic bacteria
04 agricultural and veterinary sciences
Oceanography
medicine.disease_cause
biology.organism_classification
Microbiology
chemistry.chemical_compound
chemistry
040102 fisheries
medicine
0401 agriculture, forestry, and fisheries
Fucoxanthin
Escherichia coli
Carotenoid
Bacteria
Subjects
Details
- ISSN :
- 19935021 and 16725182
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Ocean University of China
- Accession number :
- edsair.doi...........b9d74bd228a64a444eed0ef4a539b00b