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GSK-3β sets Snail's pace

Authors :
Alan Hall
Karni Schlessinger
Source :
Nature Cell Biology. 6:913-915
Publication Year :
2004
Publisher :
Springer Science and Business Media LLC, 2004.

Abstract

Snail, a transcription factor that promotes epithelial-to-mesenchymal transitions during development, has also been implicated in human cancer. A new mechanism in which GSK-3β phosphorylation regulates the rate of Snail protein degradation may provide insight into invasion and the metastatic progression of tumours.

Details

ISSN :
14764679 and 14657392
Volume :
6
Database :
OpenAIRE
Journal :
Nature Cell Biology
Accession number :
edsair.doi...........b9933520e5dfb51d2e7a9cc91cf4e87f