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Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus
- Source :
- Tetrahedron Letters. 53:6861-6864
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Prenylated indolocarbazoles have been reported neither from natural sources, nor by chemical synthetic approaches. In this Letter, we report a regiospecific prenylation of indolocarbazoles at the para- position of the indole N-atom by two recombinant enzymes from the dimethylallyltryptophan synthase (DMATS) superfamily, that is, 5-DMATS from Aspergillus clavatus and FgaPT2 from Aspergillus fumigatus .
- Subjects :
- Indole test
chemistry.chemical_classification
Aspergillus
biology
Chemistry
Stereochemistry
Organic Chemistry
biology.organism_classification
Biochemistry
Aspergillus fumigatus
Enzyme catalysis
Enzyme
Prenylation
Drug Discovery
Organic chemistry
skin and connective tissue diseases
Aspergillus clavatus
Friedel–Crafts reaction
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........b956c52682fbacdc571c48ca37f1852e
- Full Text :
- https://doi.org/10.1016/j.tetlet.2012.10.039