A Novel Hybrid System for the Fabrication of Electrospun Mat with Microspheres

In this paper, we presented a novel system of electrospinning to directly prepare fibrous meshes with micro/nanoparticles. Acetate cellulose (CA) as the material of micro/nanoparticles was dissolved in the mixture of acetone and dichloromethane as well as polyvinyl alcohol (PVA) was dissolved into deionized water, respectively. We successfully fabricated CA microspheres by an oil-in-water (O/W) emulsion/solvent evaporation technique, instilling CA solution into the stirring PVA aqueous solution. Then the hybrid solution was fabricated into a fibrous mat through electrospinning. CA micro/nanoparticles were wrapped in PVA fibers which indicated that the hybrid system of electrospinning had great potential in biomedicine when combing biodegradable microspheres with drugs.