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Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy
- Source :
- Biophysics Reports. 6:193-210
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages' proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive (i.e., pH, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents (nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.
- Subjects :
- Stimuli responsive
business.industry
Inflammatory arthritis
02 engineering and technology
General Medicine
010402 general chemistry
021001 nanoscience & nanotechnology
medicine.disease
01 natural sciences
0104 chemical sciences
Nanomaterials
medicine.anatomical_structure
Rheumatoid arthritis
Drug delivery
medicine
Cancer research
Nanomedicine
Nanocarriers
Synovial membrane
0210 nano-technology
business
Subjects
Details
- ISSN :
- 23643420 and 23643439
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Biophysics Reports
- Accession number :
- edsair.doi...........b8f8a66a62b90693be75de4be283fab0