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Retinal degeneration, apoptosis and the c-fos gene

Retinal degeneration, apoptosis and the c-fos gene

Authors :
Charlotte E. Remé
Christian Grimm
Andreas Wenzel
Farhad Hafezi
Source :
Neuro-Ophthalmology. 20:143-148
Publication Year :
1998
Publisher :
Swets & Zeitlinger Publishers, 1998.

Abstract

In the past few years, the interest in the research field of apoptosis in the retina has been growing rapidly. We will give a short overview of apoptosis in the context of retinal degeneration and summarize recent data obtained in our laboratory. Based on our findings, we will also discuss possible future strategies to influence apoptotic cell death in the retina and to modulate the time course of retinal dystrophies. Apoptosis is the final common pathway of photoreceptor cell death in several retinal dystrophies as well as in light-induced photoreceptor degeneration. We investigated potential signal transducers for apoptosis in our laboratory and found an essential role of the immediate-early gene product c-Fos in light-induced photoreceptor degeneration. This is of particular interest in light of the finding that c-fos is continuously upregulated concomitant with apoptotic photoreceptor death in animal models of the retinal dystrophy retinitis pigmentosa. Interference with c-fos expression or function m...

Details

ISSN :
1744506X and 01658107
Volume :
20
Database :
OpenAIRE
Journal :
Neuro-Ophthalmology
Accession number :
edsair.doi...........b83255feae41a2380857e48198686697
Full Text :
https://doi.org/10.1076/noph.20.3.143.4150