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Retinal degeneration, apoptosis and the c-fos gene
Retinal degeneration, apoptosis and the c-fos gene
- Source :
- Neuro-Ophthalmology. 20:143-148
- Publication Year :
- 1998
- Publisher :
- Swets & Zeitlinger Publishers, 1998.
-
Abstract
- In the past few years, the interest in the research field of apoptosis in the retina has been growing rapidly. We will give a short overview of apoptosis in the context of retinal degeneration and summarize recent data obtained in our laboratory. Based on our findings, we will also discuss possible future strategies to influence apoptotic cell death in the retina and to modulate the time course of retinal dystrophies. Apoptosis is the final common pathway of photoreceptor cell death in several retinal dystrophies as well as in light-induced photoreceptor degeneration. We investigated potential signal transducers for apoptosis in our laboratory and found an essential role of the immediate-early gene product c-Fos in light-induced photoreceptor degeneration. This is of particular interest in light of the finding that c-fos is continuously upregulated concomitant with apoptotic photoreceptor death in animal models of the retinal dystrophy retinitis pigmentosa. Interference with c-fos expression or function m...
- Subjects :
- Retinal degeneration
Retina
Gene therapy of the human retina
genetic structures
Context (language use)
Biology
medicine.disease
eye diseases
Photoreceptor cell
Ophthalmology
medicine.anatomical_structure
Apoptosis
Retinitis pigmentosa
medicine
sense organs
Neurology (clinical)
Neuroscience
Retinal Dystrophies
Subjects
Details
- ISSN :
- 1744506X and 01658107
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Neuro-Ophthalmology
- Accession number :
- edsair.doi...........b83255feae41a2380857e48198686697
- Full Text :
- https://doi.org/10.1076/noph.20.3.143.4150