Development of a Diagnostic Support Software in the Clinicobiochemical Evaluation of Secondary Amenorrhea Diagnosis

Amenorrhea is defined as the absence of menstrual bleeding and it is classified as primary, as the absence of menarche and secondary, usually longer than six to twelve months. The causes of secondary amenorrhea are pathological changes of female reproductive organs and hypothalamic-pituitary axis which, due to complex pathophysiology, are difficult to differentiate. Amenorrhea is associated with other disorders such as anxiety and depression, osteoporosis, cardiovascular diseases, endometrial cancer and infertility. Therefore, the importance of accurate diagnosis and consequent treatment is indisputable. For the purpose of accurate diagnosis, there has been developed an application based on the selected algorithm used for the evaluation of secondary amenorrhea. Algorithm allows healthcare workers and patients to make a decision on health protection based on the best evidence and to minimize costs and time frame of testing, as well. During the preparation of AmnSec application, there were used reference intervals on the following biochemical parameters: prolactin, TSH, FSH, testosterone, DHEAS and presence of virilization. The combination of default values offers the possible cause of secondary amenorrhea while the diagnostic success of the application entirely depends on the accuracy of the algorithm that the application is based on. The development of this type of application makes it easier for patients to access valid information by simply using their personal computers or mobile phones. Further work and the progress of the information sector in medicine is needed to provide more efficient, faster and better care and higher quality information for patients as the axis of improving health and life quality.