Survival and Lung Transplant Outcomes for Individuals With Advanced Cystic Fibrosis Lung Disease Living in the United States and Canada

Background Understanding how health outcomes differ for patients with advanced cystic fibrosis (CF) lung disease living in the United States compared with Canada has health policy implications. Research Question What are rates of lung transplant (LTx) and rates of death without LTx in the United States and Canada among individuals with FEV1 Study Design and Methods This was a retrospective population-based cohort study, 2005 to 2016, using the US CF Foundation, United Network for Organ Sharing, and Canadian CF registries. Individuals with CF and at least two FEV1 measurements Results There were 5,899 patients (53% male) and 905 patients (54% male) with CF with FEV1 Interpretation There are lower rates of LTx and an increased risk of death without LTx for US patients with CF with FEV1