Is There A Role of Ovarian Ablation Using Radiotherapy in the Era of Precision Medicine?

Management of Carcinoma breast has evolved over decades from Radical mastectomy to present day breast conservation surgeries and reconstructive surgeries, from 2D radiation therapy technique to present day IMRT/IGRT and Brachytherapy techniques, from toxic chemotherapy regimen to addition of taxanes and targeted therapy. Carcinoma breast is extensively studied to better the treatment options available and also to address the increasing incidence in young women. Ovarian Suppression did not take prime role in the management of cancer breast since it was mainly seen in perimenopausal who mostly attain amenorrhea after adjuvant chemotherapy and in postmenopausal women. Over the decades the incidence of carcinoma breast in young, premenopausal women has been on the rise owing to lifestyle changes, early detection by awareness programmes. Considering the changing population, the concept of ovarian suppression needs to be revisited and explored.