Interaction of selected pregna-D'-pentaranes with cytosolic receptors of myometrium and endometrium in various disease states

The relative capacities of several pregna-D'-pentaranes to combine with cytosolic receptors of the myometrium and endometrium in various disease states are investigated, and one of the compounds, 6α-methyl-16α, 17α-cyclohexanoprogesterone, is identified as holding particular promise for clinical use in replacement therapy and as a contraceptive agent.