CD4+ T cell memory restoration upon antiretroviral initiation in people living with HIV

Authors :: Alexis Thieme Sponaugle
Genevieve Clutton
Marie Iannone
Joseph Eron
Nilu Goonetilleke
Source :: The Journal of Immunology. 204:94.14-94.14
Publication Year :: 2020
Publisher :: The American Association of Immunologists, 2020.
Abstract: HIV infection causes a rapid loss of CD4+ T cells that is attributed to both direct cytotoxicity of infected CD4+ T cells and bystander loss due to high immune activation. In addition to the absolute decrease of CD4+ T cells, a significant decrease in both frequency and number of long-lived memory CD4+ T cells is observed in untreated HIV infection. Antiretroviral therapies (ART) now reliably achieve viral control (

Tools