Integrated paper-based sensing devices for diagnostic applications

Paper-based sensing platforms are one of the most powerful tools for point-of-care diagnostics. The ease of use while ensuring low production costs of such devices is the key for paper-based technologies to find their way to a successful commercialization. Thus, all steps in the analytical process chain from sample interface, sample preparation, signal amplification to signal transduction and data analysis have to be integrated in a single diagnostic platform. In this chapter, we provide a comprehensive and critical overview on recent developments towards integrated paper-based platforms in academia and industry. Herein, innovative solutions are discussed with respect to their sampling methods such as invasive and non-invasive approaches. We also address the requirements and challenges for the sampling and analysis of the different body fluids. Finally, we present our views about the future perspectives, challenges, and opportunities of the integrated paper-based devices.