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ChemInform Abstract: Diversity-Oriented Expedient Route for the Synthesis of 3-Tetrahydropyrimidinyl-Coumarins via MCR
- Source :
- ChemInform. 47
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- A practical, mild, and high-yielding synthetic approach for the synthesis of unknown tetrahydropyrimidinyl substituted 3-coumarins as hybrid scaffolds, potentially useful new chemical entities (NCEs), via metal- and catalyst-free multicomponent cyclization is described. The enhanced nucleophilicity of 3-amino coumarins versus 4-amino coumarin is explained via the difference in 13C NMR δ values (Δδ) of vinylic carbons. X-ray crystal analysis defines the structure of a representative set of example.
Details
- ISSN :
- 09317597
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........b71c8cc6b6ab3a893e2090e70d2ab22e