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Convergent syntheses of 2,3-dihydrobenzofurans via a Catellani strategy
- Source :
- Organic Chemistry Frontiers. 5:2533-2536
- Publication Year :
- 2018
- Publisher :
- Royal Society of Chemistry (RSC), 2018.
-
Abstract
- A cooperative catalytic system comprising a Pd/XPhos complex and a potassium salt of 5-norbornene-2-carboxylic acid to promote the annulation between aryl iodides and epoxides was developed, thereby providing highly convergent access to valuable 2,3-dihydrobenzofuran (DHBF) scaffolds. The unique potassium salt of the inexpensive 5-norbornene-2-carboxylic acid serves as a highly efficient catalytic mediator (10 mol%), which leads to fewer side reactions. The salient features of the reaction include its broad substrate scope (with respect to both aryl iodides and epoxides), its high atom economy and good chemo-selectivity. Furthermore, no extra base is needed for the process.
- Subjects :
- chemistry.chemical_classification
Annulation
010405 organic chemistry
Aryl
Potassium
Organic Chemistry
Salt (chemistry)
Substrate (chemistry)
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
XPhos
Atom economy
Subjects
Details
- ISSN :
- 20524129
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Organic Chemistry Frontiers
- Accession number :
- edsair.doi...........b717372c4ce83d3f662d73c2bed58172