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Successful Curative Therapy With Rituximab and Allogeneic Haematopoietic Stem Cell Transplantation for MALT Lymphoma Associated WithSTK4-Mutated CD4+ Lymphocytopenia
- Source :
- Pediatric Blood & Cancer. 63:1657-1659
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Idiopathic CD4+ lymphocytopenia and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are rare diseases in children. We report the first case of a child with STK4-mutated CD4+ lymphocytopenia who developed Epstein-Barr virus associated MALT lymphoma arising in the salivary gland. The child achieved complete remission with rituximab, and her immunodeficiency was cured by haematopoietic stem cell transplantation. The child remained well 24 months post transplantation.
- Subjects :
- 0301 basic medicine
business.industry
MALT lymphoma
Hematology
medicine.disease
Transplantation
03 medical and health sciences
Haematopoiesis
030104 developmental biology
0302 clinical medicine
Lymphatic system
Oncology
immune system diseases
hemic and lymphatic diseases
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Immunology
medicine
Rituximab
Lymphocytopenia
Stem cell
business
Immunodeficiency
medicine.drug
Subjects
Details
- ISSN :
- 15455009
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Pediatric Blood & Cancer
- Accession number :
- edsair.doi...........b7029ff0d8c164ba8a51ec4ed77d13e4