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The significant value of predicting prognosis in patients with colorectal cancer using 18F-FDG PET metabolic parameters of primary tumors and hematological parameters
- Source :
- Annals of Nuclear Medicine. 33:32-38
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The purpose was to evaluate the correlation of the pre-treatment hematological parameters with metabolic parameters of primary tumor in baseline 18F-FDG PET/CT in patients with colorectal cancer (CRC) and estimate the prognostic value of both. We retrospectively investigated 231 patients with CRC who underwent baseline 18F-FDG PET/CT. Routine blood sampling was tested in the same term. PET parameters in term of hematological parameters and pathological characteristics of primary tumor were compared. Kaplan–Meier survival analysis was performed in the patients without distant metastasis. The differences of disease-free survival between groups were compared by log-rank tests. Neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) were significantly correlated with all the metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and tumor lesion glycolysis (TLG). The patients with NLR > 3 had higher MTV (24.82 ± 18.16 vs 19.06 ± 13.30, P = 0.039) and TLG (219.04 ± 186.94 vs 166.45 ± 146.39, P = 0.047) than those whose NLR ≤ 3. NLR in those patients with distant metastasis was significantly higher than those without distant metastasis (P = 0.018) while LMR in those patients with distant metastasis was significantly lower than those without distant metastasis (P = 0.032). Survival analysis showed that those patients with low MTV (P = 0.015), low NLR (P = 0.008) and high LMR (P = 0.027) revealed significant survival benefit. There was a significant association between the pre-treatment hematological parameters and metabolic parameters of baseline 18F-FDG PET/CT in the patients with CRC. It might be helpful in those patients with high NLR and low LMR to undergo 18F-FDG PET/CT to detect distant metastasis and predict prognosis.
- Subjects :
- medicine.medical_specialty
business.industry
Colorectal cancer
Standardized uptake value
General Medicine
medicine.disease
Primary tumor
Gastroenterology
030218 nuclear medicine & medical imaging
Lesion
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
Medicine
Radiology, Nuclear Medicine and imaging
In patient
medicine.symptom
business
Pathological
Survival analysis
Blood sampling
Subjects
Details
- ISSN :
- 18646433 and 09147187
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Annals of Nuclear Medicine
- Accession number :
- edsair.doi...........b63f2f1544a19d02b5a05093c0955844
- Full Text :
- https://doi.org/10.1007/s12149-018-1299-z