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Validation of obesity susceptibility loci identified by genome-wide association studies in early childhood in South Brazilian children
- Source :
- Pediatric Obesity. 12:85-92
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- SummaryBackground The prevalence of childhood obesity has been dramatically increasing in developing countries as it has been reported for developed nations. Identifying susceptibility genes in early life could provide the foundations for interventions in lifestyle to prevent obese children to become obese adults. Objectives The objective of this study was to evaluate the influence of genetic variants related to obesity identified by genome-wide association studies (MC4R, TMEM18, KCTD15, SH2B1, SEC16B, BDNF, NEGR1, OLFM4 and HOXB5 genes) on anthropometric and dietary phenotypes in two Brazilian cohorts followed-up since birth. Methods There were 745 children examined at birth, after 1 year and after 3.5 years of follow-up. Ten single nucleotide polymorphisms were genotyped. Anthropometric and dietary parameters were compared among genotypes. Children were classified as overweight when body mass index Z-score was >+1. Results Overweight prevalence was 30.7% at 3.5 years old. Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes and at 3.5 years old for SEC16B rs10913469 with dietary parameters. Conclusions Our results indicate that genetic variants in/near these genes contribute to obesity susceptibility in childhood and highlight the age at which they begin to affect obesity-related phenotypes.
- Subjects :
- 0301 basic medicine
Nutrition and Dietetics
business.industry
Health Policy
Public Health, Environmental and Occupational Health
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Genome-wide association study
Overweight
medicine.disease
Obesity
Childhood obesity
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Pediatrics, Perinatology and Child Health
Genetic predisposition
Medicine
medicine.symptom
business
Body mass index
Demography
Genetic association
Subjects
Details
- ISSN :
- 20476302
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Pediatric Obesity
- Accession number :
- edsair.doi...........b61b5a5ecf61ce3c9b90e434210fb281