Catalytic Asymmetric [4+1] Spiroannulation of α-Bromo-β-Naphthols with Azoalkenes by an Electrophilic Dearomatization/S RN 1-Debromination Approach

Authors :: Lu Bai
Yicong Ge
Jingjing Liu
Xinjun Luan
Xin Luo
Yao-Yu Wang
Hui Wang
Source :: CCS Chemistry. 4:1054-1064
Publication Year :: 2022
Publisher :: Chinese Chemical Society, 2022.
Abstract: An enantioselective [4+1] spiroannulation of α-bromo-β-naphthols with azoalkenes has been developed for the one-step construction of a new class of pyrazoline-based spirocyclic molecules. Using chi...

Subjects :: chemistry.chemical_compound
Radical-nucleophilic aromatic substitution
chemistry
Electrophile
Enantioselective synthesis
Molecule
Pyrazoline
General Chemistry
Combinatorial chemistry
Catalysis

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