Back to Search Start Over

Efficacy of Intraperitoneal and Intravenous Administration of Antitumor Drugs in Rats with Peritoneal Carcinomatosis

Authors :
Belyaeva Oa
Vladimir G. Bespalov
A M Belyaev
G. S. Kireeva
A. N. Stukov
A. L. Semenov
Irina N. Vasilyeva
Ekaterina A. Vyshinskaya
Source :
Annals of Oncology. 25:v102
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

Background: Intraperitoneal (i.p.) chemotherapy in patients with peritoneal carcinomatosis could be an more effective treatment strategy than intravenous (i.v.) chemotherapy. The purpose of the study is to compare antitumor activity of different drugs at their i.p. and i.v. administration in rats with peritoneal carcinomatosis. Metods: The study was carried out in 100 Wistar female rats with ovarian cancer which was inoculated intraperitoneally (i.p.) to simulate peritoneal carcinomatosis. Transplanted epithelial ovarian cancer strain used was originated from the rat subjected to transplacental administration of 7,12-dimethylbenz(a)anthracene. After ovarian cancer inoculation rats were randomized in 10 groups, 10 rats in each group. There were five groups where saline (2 ml, i.p. control group) or the drugs (dioxadet 1.5 mg/kg, cisplatin 4mg/kg, melphalan 2 mg/kg, mitomycin C 1.5 mg/kg) were administered i.p. In other five groups saline (2 ml, i.v. control group) and the named above drugs at the same doses were administered i.v. Dioxadet is original Russian antineoplastic drug from the group of ethyleneimine alkylating agents. Antitumor effects of the treatment were estimated by increase in survival time (IST) comparing median survival time of rats in different groups. Results: IST for i.p. administration of dioxadet, cisplatin, melphalan and mitomycin C were 76.5% (p Conclusion: I.p. chemotherapy with alkylating agents dioxadet, cisplatin and melphalan is much more effective then their i.v. administration while antitumor antibiotic mitomycin C is more active at i.v. administration.

Details

ISSN :
09237534
Volume :
25
Database :
OpenAIRE
Journal :
Annals of Oncology
Accession number :
edsair.doi...........b5da93174842003e66b4aa2dec811786
Full Text :
https://doi.org/10.1093/annonc/mdu436.122