In vitro Antifungal Activity of Combination of Miconazole, Salicylic Acid and Benzoic Acid in Two Different Bases against Trichophyton mentagrophytes

In vitro activity of miconazole, salicylic acid and benzoic acid against T.richophyton mentagrophytes was done on Sabouraud’s dextrose agar. The inhibition zones were measured in cm. 2.8 cm, 1.5 cm and no inhibition zone were reported for miconazole, salicylic acid and benzoic acid respectively. Synergistic effect of salicylic acid and benzoic acid against T. mentagrophytes was done using two different bases of cream lanette 20% and aqueous cream 30/70. Four different formula each one contain 2% miconazole with different concentrations of salicylic acid and benzoic acid were used. Biggest inhibition zone (5 cm) was observed of lanette cream which contains 2% miconazole, 3% salicylic acid and 6% benzoic acid.