450 ZINC (Zn) AND BIRTH DEFECTS (BD)

Zn deficiency has been reported in infants with BD and in children born with achondroplasia. 304 families were studied comparing parental age, Zn nutritional status and infant weight at the time of birth. There is a statistically significant correlation (p < .01) between infant hair Zn and maternal age at time of birth. The decrease in infant hair Zn seen with teenage (14-20) and elder mothers (31-40) may be related to the incidence of increased BD which occurs in these groups. Infant hair Zn was lowest in the heaviest infants and in a group with BD made up of porencephaly, anencephaly and microcephaly as the presenting sign (N=4; Zn=134±10). The heavier children may represent the infants of potential diabetic mothers (who have more BD). Placental Zn was 18-19 ug/g and did not correlate well with maternal or infant hair Zn. Finally, diet did not explain parental Zn status since paired deficiencies did not occur. Therefore, an association between Zn levels, high-risk age groups and those children with BD is apparent.