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Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase
- Source :
- Bioorganic & Medicinal Chemistry Letters. 2:69-72
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- By replacing the carboxylic acid functionality of several fenamates with 1,3,4-oxadiazole-2-thiones and 1,3,4-thiadiazole-2-thiones we converted selective cycloxygenase (CO) inhibitors ito dual inhibitors of both CO and 5-lipoxygenase (5-LO).
Details
- ISSN :
- 0960894X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........b52c84813e12191fad55054145533988
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)80657-5