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Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits
- Source :
- Journal of Orthopaedic Research. 28:812-818
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The purpose of this study was to compare the effects of estrogen deficiency and bone mass loss on normal knee cartilage in mature rabbits. Bilateral ovariectomy (OVX) was performed in 13 rabbits, 6 of which also received systemic glucocorticoid for 4 weeks. Seven additional healthy rabbits were used as controls. Bone mineral density (BMD) was measured by dual X-ray absorptiometry in lumbar spine, knee, and subchondral bone of the knee at baseline and 22 weeks after OVX. After sacrifice, the knees were dissected, macroscopy was assessed, and histological cartilage abnormalities were evaluated according to the Mankin score. Correlations of Mankin with BMD at different regions were also performed. When compared to baseline, differences in BMD were only found in spine and knee of the animals receiving glucocorticoids. All the animals subjected to OVX had a significantly higher Mankin score than controls. Mankin was upper in OVX animals receiving glucocorticoids, but differences were not significant. The Mankin score was inversely related with BMD in lumbar spine (r = -0.67; p < 0.01). Although low bone mineral density contributes to the minor osteoarthritic alterations observed in our model, estrogen deficiency itself seems to act directly to induce the main pathogenic effects in healthy cartilage of the rabbit.
- Subjects :
- musculoskeletal diseases
Bone mineral
medicine.medical_specialty
medicine.diagnostic_test
Bone density
medicine.drug_class
business.industry
Cartilage
Osteoporosis
Magnetic resonance imaging
Knee Joint
musculoskeletal system
medicine.disease
medicine.anatomical_structure
Endocrinology
Estrogen
Internal medicine
medicine
Orthopedics and Sports Medicine
business
hormones, hormone substitutes, and hormone antagonists
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 07360266
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Orthopaedic Research
- Accession number :
- edsair.doi...........b4e68a2bc1a39448edc07974b95da668